He was trained by his uncle Rey Misterio and wrestled early on in Mexico, where he learned the Lucha Libre high flying style that has been his trademark.

[21] He successfully defended the title against Ultimate Dragon at Hog Wild on August 10,[22] Malenko at Clash of the Champions XXXIII five days later,[23] and Super Caló at Fall Brawl on September 15.

[26] On February 23, 1997, he faced Prince Iaukea for the WCW World Television Championship at SuperBrawl VII, but lost after being attacked by Lord Steven Regal.

[31] On the January 15, 1998, episode of WCW Thunder, Mysterio defeated Juventud to win his third Cruiserweight Championship, but lost it nine days later to Chris Jericho at Souled Out.

[30] On the March 22 episode of Nitro, Mysterio got his first shot at the WCW World Heavyweight Championship against champion Ric Flair when the names of (allegedly) nearly everyone in the company were put into a hat and a lottery was held.

[30] At Slamboree on May 9, Mysterio and Kidman lost the World Tag Team titles to Raven and Perry Saturn in a triangle match, also involving former champions Benoit and Malenko.

[48][49] After Master P's departure from WCW, Mysterio formed a stable with Eddie Guerrero and Billy Kidman known as the Filthy Animals, turning heel for the first and only time in his career.

[50] The Filthy Animals defeated Dead Pool in six-man tag team matches at Road Wild on August 14 and Fall Brawl on September 12.

[64] On the final episode of Nitro on March 26, they defeated Skipper and Romeo in a rematch to win the Cruiserweight Tag Team Championship before WCW was sold to the World Wrestling Federation (WWF).

[96] On the April 21 episode of SmackDown!, Mysterio and Guerrero lost the WWE Tag Team Championship to MNM (Joey Mercury and Johnny Nitro).

along with Randy Orton, Bobby Lashley, Batista, and John "Bradshaw" Layfield (JBL), defeating Team Raw (Shawn Michaels, Kane, Big Show, Carlito, and Chris Masters).

[115] On the December 30 episode of SmackDown!, MNM invoked their rematch clause, defeating Batista and Mysterio after interference from Mark Henry to regain the WWE Tag Team Championship.

[133] In their main event match, Mysterio retained the World Heavyweight Championship, causing JBL to leave SmackDown!, until ECW One Night Stand on June 11, when he announced his return as a color commentator.

[166] Mysterio then made his in-ring return at Unforgiven on September 7, competing in the World Heavyweight Championship scramble match, which was won by Chris Jericho.

[183] Later that month, Mysterio returned and was revealed as Batista's partner in a match against Jeri-Show (Chris Jericho and Big Show) for the Unified WWE Tag Team Championship at Hell in a Cell on October 4, which they lost.

[196] At Fatal 4-Way on June 20, Mysterio defeated Jack Swagger, Big Show, and CM Punk to win the World Heavyweight Championship for the second time.

[218] On April 26, 2012, WWE reported that Mysterio had been suspended for 60 days due to his second violation of the company's Talent Wellness Program policy and that his suspension would expire on June 25.

[219] After his return in July,[220] Mysterio faced The Miz for the Intercontinental Championship at SummerSlam on August 19 and in a fatal-four-way match at Night of Champions on September 16, but lost both times.

[231][232] At TLC: Tables, Ladders and Chairs on December 15, Mysterio and Big Show unsuccessfully challenged Cody Rhodes and Goldust for the WWE Tag Team Championship in a fatal four-way match also involving RybAxel (Ryback and Curtis Axel) and The Real Americans.

[249] Despite not working directly for AAA, Mysterio Jr. participated in the 2016 Lucha Libre World Cup alongside Dr. Wagner Jr. and Dragon Azteca Jr., known as "Team Mexico International"; the trio finished in third place.

[259] On January 10, 2016, Mysterio, Dragon Azteca Jr. and Prince Puma defeated Ivelisse, Johnny Mundo and Son of Havoc and Fénix, Jack Evans, and P. J.

[272] Mysterio participated in the WWE World Cup at Crown Jewel on November 2,[273] defeating Randy Orton in the first round but lost to The Miz in the semi-finals.

[285][286] After being drafted to Raw as part of the Superstar Shake-up,[287] Mysterio won the title from Joe at Money in the Bank on May 19, becoming the twenty-first WWE Grand Slam Champion in the process.

[290] On the September 23 episode of Raw, Mysterio won a fatal five-way elimination match, earning him a Universal Championship opportunity against Seth Rollins.

[312] On the June 4 episode of SmackDown, the Mysterios retained their titles against The Usos, albeit with controversy as the referee failed to notice Jimmy's shoulder was lifted.

After Adam Pearce and Sonya Deville granted a rematch later that night, the Mysterios again retained their titles after Roman Reigns interfered and attacked them, causing a disqualification.

[324] Over the following weeks, The Mysterios began a feud with The Judgment Day (Finn Balor, Damian Priest, and Rhea Ripley), who repeatedly attempted to have Dominik join the stable.

[338] In July, Mysterio competed in the United States Title Invitational Tournament, where he was defeated by LWO stablemate Escobar in the finals via referee stoppage, after suffering from whiplash.

[343] At Fastlane on October 7, Mysterio, Escobar and the returning Carlito defeated Bobby Lashley and The Street Profits in a six-man tag team match.

While the Wellness Policy allows for prescribed drugs, Gutierrez further contested he had been on a family holiday and subsequently in Europe promoting SummerSlam, giving him only a day to provide the prescription after being notified.