[4] Maroto worked in the Ideas for Progress Foundation between 2011 and 2013,[5] and has been an associate professor in the Department of Economics at the Charles III University of Madrid.

[6][7] Candidate number 20 on the list of the Spanish Socialist Worker's Party (PSOE) for the regional elections of May 2015 in the Community of Madrid,[8] Marto was elected and became deputy of the Assembly of Madrid, in which she served as socialist spokeswoman in the Committee of Budgets, Economy, Finance and Employment.

[10] Felipe VI sanctioned her appointment as holder of the portfolio of Industry, Commerce and Tourism by royal decree,[11] becoming the first woman to held the post.

[12][13] On 26 April 2021, Reyes Maroto received an envelope with a bloodstained razor or knife, days after Minister of Interior Fernando Grande-Marlaska, former Second Deputy Prime Minister Pablo Iglesias, and Director of the Guardia Civil María Gámez received envelopes with bullets inside of them.

[16] Her comments caused widespread criticism, because the Cumbre Vieja volcano is dotted with numerous homes, public buildings and businesses which began to be destroyed by the lava flows.