Reyno is a city[3] in Randolph County, Arkansas, United States.

The name was changed again, this time to Reyno, a shortened version of Reynolds, named for Dennis Wells Reynolds, a merchant who opened the town's first store and built the first home there in 1857.

[4] In 1901, the town relocated to its present site to be adjacent to the newly built St. Louis-San Francisco Railway there.

Upon relocation, the new town adopted the name of Esselwood, but reverted to Reyno due to the majority of residents moving from the previous location.

[6] According to the United States Census Bureau, the town has a total area of 2.6 km2 (1.0 mi2), all land.

23.8% of all households were made up of individuals, and 10.4% had someone living alone who was 65 years of age or older.