The Rhett House Inn, is historic building in Beaufort, South Carolina.

It is significant as the home of Thomas Moore Rhett and his wife, Caroline Barnwell, who were early pioneers in South Carolina in the 1800s.

[2] Rhett owned a plantation on the Ashepoo River with enslaved African Americans living and working on the property.

In 1850, Rhett advertised in The Charleston Mercury giving a fifty dollar reward for the apprehension and delivery to the nearest jail of a slave named Sampson.

The Inn sits on a masonry basement with a porch on the south and west sides and faces the Beaufort River.