Route 101 is a numbered state highway running 9.7 miles (15.6 km) in Rhode Island.

It runs from the Connecticut state line east to U.S. Route 6 (US 6) in the town of Scituate.

Route 101 passes near Jerimoth Hill, the highest point in Rhode Island.

In the 19th century, modern Route 101 was a toll road that was administered by the Rhode Island and Connecticut Turnpike corporation.

Signage westbound at that intersection has now been changed to say "TO Route 101", leading to the belief that the western terminus is now the split between Hartford Pike and the US 6 Bypass, where the concurrency ended.