[3] Though non-toxic,[5] this species is considered inedible due to its toughness and unpalatability;[6] it is typically bitter.

[7] In 2016, Gupta et al. reported that collybolide exhibited high-potency, selective kappa-opioid receptor (KOR) agonism.

[8] Due to its attractive bioactivity and chemical similarity to salvinorin A, collybolide garnered attention in the synthetic chemistry and pharmacology fields as a potential scaffold for developing next-generation analgesics, antipruritics, and antidepressants.

Despite previous findings by Gupta et al., these assays showed that neither enantiomer of collybolide had KOR activity.

[11][Note 1] These assays of synthetic and natural samples contradict the findings of Gupta et al., and suggest that collybolide and the other constituents of R. maculata have no activity at KOR.