Rhombophryne serratopalpebrosa is a species of frog of the Madagascar endemic microhylid subfamily Cophylinae.

[3][5][1] Rhombophryne serratopalpebrosa is endemic to the Marojejy massif in northern Madagascar.

[3] The holotype of Rhombophryne serratopalpebrosa measures roughly 29 mm (1.1 in) long.

[6] Plethodontohyla serratopalpebrosa was transferred to the genus Rhombophryne by Wollenberg and colleagues.

[4][5] The closest relative is suspected to be R. regalis, which is smaller but shares certain morphological characters such as an s-shaped fold posterior to the nostril,[5] but their relationship is uncertain due to the lack of genetic material from R.