Ribera del Guadiana is a Spanish Denominación de Origen Protegida (DOP) for wines located in the region of Extremadura (Spain).

The Cañamero sub-zone covers 5 municipalities in the Sierra de Guadalupe range to the east of the province of Cáceres at an elevation of over 800 m above sea level.

The land comprises hills and valleys, with rich, brown, slightly acidic soil at an elevation of about 625 m above sea level.

The soils are similar to those in Tierra de Barros, while the climate is cooler due to the higher elevation of over 600 m above sea level.

The DOP Regulatory Council authorizes the use of 39 different grape varieties, some of which are native to the area and are not grown in the rest of Spain.