[2] Wyatt was born in Los Angeles and graduated from Johns Hopkins University Medical School[2] and joined the National Institutes of Health (NIH) in 1967, where he established a schizophrenia research program.
[1] He was one of the early pioneers who studied the biological basis of schizophrenia in the lab.
[2] His research led to the first evidence that monoamine oxidase inhibitors (MAOIs) suppressed REM sleep and could treat narcolepsy.
[2] He was a prolific writer, educator and teacher, having authored over 800 research articles and 6 books and he has trained many of today's leading neuroscientists.
He was married to Rollyn Simon Wyatt and later to clinical psychologist and author Kay Redfield Jamison.