[2] Bacteria with 16S ribosomal RNA highly similar to the Rikenella genus, as compared to the larger taxonomic order Bacteroidales, are classified in this family.
[1] This family consists of non-motile, rod-shaped bacteria that are tolerant of bile.
[3] Bacteria of this taxonomic family are elevated in the gut microbiomes of mice that are leptin-resistant obese and diabetic.
[4] However, Rikenellaceae bacteria are depleted in the gut microbiomes of obese American adults, leading to reduced synthesis of butyrate and disrupted metabolism.
[5] Gut microbiomes with elevated levels of Rikenellaceae bacteria are associated with lupus and Alzheimer's disease in mice and colorectal cancer in humans.