On 1 July 1865, the Bologna–Ancona railway, including the station, came under the control of the Società per le Strade Ferrate Meridionali.

[1] This development, coupled with growth in passenger traffic, created the need for an expansion of the station and its facilities, and the construction of other outbuildings.

Soon enough, a further increase in traffic made it essential to move the passenger building to the south of the locomotive depot and workshop, where there was enough space for a new station yard with wider platforms.

In late 1938, in conjunction with electrification of the Bologna–Ancona railway, important works were carried out to upgrade the station's facilities.

[citation needed] During World War II, the station and its surrounds were repeatedly hit by Allied aerial bombardment.

Since the start of the 21st century, some tracks and the locomotive shed have been closed, and the goods yard converted into a car park.

Centostazioni has recently been renovating the passenger building with a simultaneous internal reorganization and change of use to the character of a shopping centre.

In August 2021, two billboards were installed at the station, featuring illustrations of Emiliano Ponzi and quotes from Marco Missiroli [it].

[4] There are infrequent or seasonal direct trains to San Pietro in Casale, Ferrara, Suzzarra, Torino Porta Nuova, Venezia Santa Lucia, and Trieste Centrale.

[4] One high-speed Frecciabianca runs to Roma Termini every morning, returning as a non-stop service to Ravenna in the evening;[4] in November 2023,[5] Trenitalia announced that the route would be upgraded to Frecciargento.

[13] Following the bombing of the line's maintenance depot on 26 and 27 November 1943,[13] services were shortened to a flagman's booth by the Via Flaminia, which was reclassified as a stop, thereby avoiding the city centre.

[21][22] On 15 October 1960, the railway was closed and replaced with a bus service,[19] having run for some years with irrecuperable deficits.