[7] The river runs in a southerly direction parallel to Puerto Rico route PR-123, the old road from Adjuntas to Ponce.

Continuing south and running parallel to Route 123, the river enters the city of Ponce in the area of barrio Magueyes Urbano (the urban zone of barrio Magueyes) before approaching PR-132, the country road from Ponce to Peñuelas.

The river then runs parallel to Jardines del Caribe's East Main Street, and crosses Avenida Las Americas (PR-163), next to the intersection of PR-163 and PR-500.

Less than one mile further south Río Matilde empties into the Caribbean Sea at barrio Playa.

Roads are listed as the river flows from its origin in Cerro Avispa, in Barrio Guaraguao, north of the city of Ponce, until the river feeds into Rio Matilde in Barrio Canas in the south (N/A = Data not available): *Marker requires field verification.