Rio Grande Preparatory Institute (RGPI) is an alternative high school[1] in Mesilla, New Mexico.

RGPI was once host to the public library of Mesilla from 2012 to 2014, when the school forced the closure due to security concerns.

[3] In 2021, the gymnasium was painted with an ohmage to four major figures in Las Cruces Public Schools, including former superintendent Karen Trujillo and former Las Cruces High School principal Jim Hendee.

[4] In 2023 Las Cruces High School principal Michelle Ronga was brought in, a position still held by her as of July 2024.

[6] RGPI reduces teacher-student ratios, focusing on one-on-one interactions, meant to foster creativity and original thinking.