Its basin extends across the northern portion of Coahuila, Nuevo Leon, and Tamaulipas states.

It originates in the Sierra Madre Oriental in Coahuila and flows east-northeastward.

It is joined by the Rio Sabinas in the reservoir created by the Venustiano Carranza Dam.

The Salado flows southeast from the reservoir through northern Nuevo León and northwestern Tamaulipas, where it is joined by the Sabinas Hidalgo River, to join the Rio Grande in the Falcón Reservoir, at Rio Grande river kilometer 43.

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