The octagonal tiburium (corridor across base of cupola drum) dates to 1786, the Neoclassical façade to 1842, while the bell-tower was built from 1884 to 1902.
The wooden pulpit with panels depicting the five glorious mysteries was carved by D. Bonfini of Patrignone.
The main altar has two paintings, a 17th-century canvas depicting San Gregorio Magno and an 18th-century Nativity.
Among other works in the church are a polychrome wooden crucifix putatively donated by Pope Pius V in 1571 and attributed to Giovanni Battista Casignola.
The aedicule, designed by Francesco Vespignani in 1881, houses the venerated Simulacro (1620), a work of S. Sebastiani.