It provides education for ninth through twelfth grades for the town of Lexington and parts of Lake Murray, Oak Grove and West Columbia.

It is located on the eastern side of Lexington, the school overlooks the Saluda River and is a few hundred feet from Interstate 20 and U.S. Highway 378.

[citation needed] River Bluff is one of the largest schools in South Carolina, covering an area of 540,000 square feet (50,000 m2).

[6] In 2021, while exploring school grounds, a group of students discovered the graves of numerous Black South Carolinians dating back to the 1800s.

[7] A landmark was later added to the area to commemorate the historically black Mount Zion AME Church/graveyard which had stood on the school's grounds from 1857 to 1929.