The Brisson River (French: Rivière Brisson) flows in the Réserve faunique Duchénier and in the municipality of Esprit-Saint, in the Rimouski-Neigette Regional County Municipality, in the administrative region of Bas-Saint-Laurent, in the province of Quebec, in Canada.

The Brisso river "rises at the mouth of Chasseur lake (length: 1.4 km (0.87 mi); altitude: 295 m (968 ft)), in the Duchénier Wildlife Reserve, in the Notre Dame Mountains.

This lake is fed by the outlet of Lac Ovale (altitude: 304 m (997 ft)) and is located in the heart of the Duchénier Wildlife Reserve.

This confluence is located 33.8 km (21.0 mi) southeast of the southeast coast of the St. Lawrence River, 3.9 km (2.4 mi) north of the village center of Esprit-Saint, 7.4 km (4.6 mi) west of the village center of La Trinité-des-Monts.

The toponym "Rivière Brisson" was formalized on June 11, 1982, at the Commission de toponymie du Québec.