Since the middle of the 19th century, forestry has been the main economic activity in this sector.

In the 20th century, recreational and tourist activities have been highlighted, because the territory has been integrated into the zec Wessonneau.

Some forest roads serve this valley for forestry and recreational tourism purposes.

The neighboring watersheds of the Wessonneau du Milieu River are: In its course, the Wessonneau du Milieu crosses several lakes, in particular: Montreal, Nelson, Thomas (neighbor of Lac Sauvageau), Lac Geoffrion, a small unnamed lake, Lac Ann, and Charlemagne.

From its mouth, the river flows over: The discharge from the latter lake descends on 110 m (360 ft) to flow to the southeast into Nelson Lake (1.1 km (0.68 mi) long, oriented to the southeast; altitude: 424 m (1,391 ft)) that the current crosses.