The Rivière de la Grande Loutre is a tributary of the Péribonka River, flowing in the unorganized territory of Passes-Dangereuses, in the Maria-Chapdelaine Regional County Municipality, in the administrative region of Saguenay–Lac-Saint-Jean, in the province of Quebec, in Canada.

The upper part of the watershed of the Grande Loutre river is served by the forest road R0206 (north–south direction) which passes between Dubray Lake and lac de Bransac.

A few secondary roads serve the area for forestry and recreational tourism purposes.

The main neighboring watersheds of the Grande Loutre river are: The Grande Loutre river takes its source at the mouth of Dubray Lake (length: 5.3 km (3.3 mi); altitude: 553 m (1,814 ft)) in the unorganized territory of Passes-Dangereuses, or to: From its source (Lake Dubray), the Grande Loutre river flows over 72 km (45 mi) on a drop of 106 m (348 ft) entirely in the forest zone, according to the following segments: Upper course of the Grande Loutre river (segment of 16.6 m (54 ft)) Intermediate course of the Grande Loutre river (segment of 32.0 m (105.0 ft)) Lower course of the Grande Loutre river (segment of 9.4 m (31 ft)) The Grande Loutre river flows onto the west bank of the Péribonka river, at: From the mouth of the Grande Loutre river, the current descends the course of the Péribonka river on 345.5 km (214.7 mi) towards the south, crosses Lake Saint-Jean on 29.3 km (18.2 mi) eastward, then on 155 km (96 mi) follows the course of the Saguenay River eastward to the height of Tadoussac where it meets the Saint Lawrence River.

[1] The toponym of "Rivière de la Grande Loutre" was made official on March 3, 1971, at the Place Names Bank of the Commission de toponymie du Québec.