The show follows the adventures of the Road Rovers, a team of five super-powered crime-fighting anthropomorphic dogs, known as "cano-sapiens".

One year later, as Parvo mutates normal dogs into monsters, Shepherd, who miraculously survived the attack, takes measures to stop him.

Shepherd selects five different dogs and in his new, secret underground lab, he uses his new transdogmifier on the five, turning them into "Cano sapiens."

These dogs are the pets of world leaders, and when called to action, they are a team of crime fighters known as the Road Rovers.

A statue of Hunter makes a cameo appearance in The Sylvester & Tweety Mysteries episode "The Stilted Perch".