He is an author of many popular Armenian songs ("Hayreni yerkir", "Hayi achker", "Ding-dong", "Arise!

", "Arevot andzrev"),[2] soundtracks of films, animation cartoons, operettas, as well as the first Armenian musical, entitled “The Oriental Dentist”.

His songs were performed by Raisa Mkrtchyan, Muslim Magomayev, Larisa Mondrus.

[3] Amirkhanyan's "Variations for String Quartet" won the first prize in the Young Composers' Competition of the USSR in 1969.

In 1975 his composition "Autumn Melody" won the 3rd prize at the Sopot International Song Festival.