Colonel Robert Patterson (1753 – 1827) was an American soldier and settler who helped found the cities of Lexington, Kentucky and Cincinnati, Ohio.
He took part in George Rogers Clark's celebrated Illinois campaign in 1778, and fought in many other actions during the war.
Patterson then moved to Dayton, Ohio, in 1802 and continued his military service as a quartermaster during the War of 1812.
Patterson's farm, Rubicon, was located two miles south of Dayton where he and his wife Elizabeth (Lindsay) raised eight children.
Patterson's granddaughter Eliza Jane (Brown) Anderson was the First Lady of Ohio 1865–1866.