Robert Reed Squires (January 11, 1953 – September 30, 1998) was an American chemist known for his work in gas phase ion chemistry and flowing afterglow mass spectrometry.

He then went on to Yale University where he worked in the laboratory of Kenneth B. Wiberg on the thermochemistry of organic compounds.

He took a postdoctoral position with Charles DePuy and Veronica Bierbaum at the University of Colorado, Boulder where he studied the reactions of gas-phase ions using the flowing afterglow technique.

Among his awards were an Alfred P. Sloan Foundation Fellowship in 1987, the American Chemical Society Nobel Laureate Signature Award for Graduate Education in Chemistry (with Susan Graul) in 1991, and the American Society for Mass Spectrometry Biemann Medal in 1998.

The Purdue University Department of Chemistry Robert R. Squires Scholarship was established in his honor.