[3] Born in Benevento from humble parents, Pedicini and his family moved to Pescara when he was young.

Still a teenager, he made most of his living as a wandering street performer, singing while accompanying himself with the guitar,[4] and gained experience as a radio host.

He was soon cast as a voice actor in many roles, while his onscreen acting debut happened 8 years later, in Lamberto Bava's horror cable series Brivido Giallo.

Pedicini is best known as a voice dubber, serving as the official Italian voice actor of Kevin Spacey and Jim Carrey; he also regularly dubs Woody Harrelson, Javier Bardem, Ralph Fiennes, Temuera Morrison and Ricky Gervais in most of their movies.

In Pedicini's animated roles, he has dubbed both Sylvester the Cat and the Tasmanian Devil from 1996 until 2022 and has been the official Italian voice of Goofy since 1999 (replacing Vittorio Amandola), as well as Timon in most of his cartoons, Phoebus in The Hunchback of Notre Dame, Hopper in A Bug's Life and Gaston in Beauty and the Beast, also voicing Scarpa in the Italian animated film How the Toys Saved Christmas.