An opening batsman, Mukherjee played his first first-class match in 1964-65 for Railways against Jammu and Kashmir, scoring 90 not out in the second innings before his captain declared.
[2] In 1967-68, on his first appearance for State Bank of India in the Moin-ud-Dowlah Gold Cup Tournament, he made 183 in 260 minutes, putting on 233 for the third wicket with Hanumant Singh.
In 1970-71 he made 288 runs at 48.00 in the Ranji Trophy as Bihar progressed to the semi-finals for only the third time.
Against Mysore in the quarter-final he scored 130 to help Bihar to a two-run first-innings lead and a place in the semi-final, which they lost to Punjab.
Later he served as a selector for Bengal and as chief curator of pitches for East Zone.