[7] Other theatre credits include Pride's Crossing, A Place at the Table, Hamlet, Arms and the Man, Goodnight Children Everywhere, The Seagull, Madame Melville (Drama Desk and Lucille Lortel Award nominations),[8] as well as Jon Robin Baitz's Other Desert Cities at the Mark Taper Forum in 2012, directed by Robert Egan.

[9] After a decade as a stage actress based in New York City, Weigert moved to Los Angeles and has appeared in various films, television shows and mini-series.

[citation needed] Weigert played therapists in the box office hit Smile and opposite Nicole Kidman in the much-lauded HBO TV series Big Little Lies, attorneys in the popular cabler Sons of Anarchy and Jay Roach's biographical drama Bombshell, and strippers in Charlie Kaufman's Synecdoche, New York and Steven Soderbergh's black-and-white period drama The Good German.

She was nominated for a Gotham Award for her portrayal of the central character, a housewife turned prostitute, in the award-winning indie Concussion, and was featured prominently in the Hulu miniseries We Were the Lucky Ones in which she plays the matriarch of a Polish Jewish family that survived the Holocaust.

Series regular roles include Dietland for AMC with Julianna Margulies, NBC's Life with Damian Lewis, and CBS' Tracker with Justin Hartley.