Rock Creek is an 82-mile (132 km) tributary of the John Day River in the U.S. state of Oregon.

The source of the creek is at an elevation of 4,351 feet (1,326 m) in the Umatilla National Forest, while the mouth is at an elevation of 404 feet (123 m) east of Wasco.

Rock Creek has a 507-square-mile (1,310 km2) watershed.

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