[3] Mayol accumulated a record of 22-0 before losing his first world title bout to WBC minimumweight champion Eagle Den Junlaphan by unanimous decision on May 6, 2006.
On August 4, 2007, Mayol challenged Ulises Solís for the IBF light flyweight title but lost by 8th-round technical knockout.
On November 21, 2009, he won the WBC light flyweight title by stopping reigning champion Edgar Sosa in two rounds in Mexico.
[4] Sosa, who required a metal plate to be implanted on his cheekbone due to multiple fractures suffered from the headbutt, filed a protest with the WBC to have the decision changed to a "no contest".
[8] He fought Omar Nino Romero on February 27, 2010, for his first defense of the WBC light flyweight title at the Coliseo Olimpico de la UG in Guadalajara, Jalisco, Mexico.
[9] On June 19, 2010, Mayol lost his title in a rematch with Romero in San Juan del Rio, Queretaro, Mexico.