He married in October 1622 with Isabel Fernández of Híjar, granddaughter of Ana de Mendoza, Princess of Eboli.
[1] Despite being an adversary of Olivares, he received in 1640 a military command in the War against Portugal.
He had the ambition to succeed Olivares as Valido and plotted against his successor Luis de Haro.
Because of this, he was condemned to life imprisonment in the Castle of León, while Padilla and Domingo Cabral were executed.
Híjar died in prison, which seems harsh compared to the lenient sentence given to Gaspar Alfonso Pérez de Guzmán, 9th Duke of Medina Sidonia in 1641 for his part in the Andalusian independentist conspiracy (1641).