Following a career in the FBI, he served on the panel investigating the Virginia Tech shooting and its handling by the university.

Depue is the coauthor of Between Good and Evil: A Master Profiler's Hunt for Society's Most Violent Predators.

[1]This led him to coin the term "leakage", which basically means that people's fantasies tend to leak into behavior.

One of Dupue's most important contributions involved the cold case of Terri Brooks.

With DNA evidence, Officer Nelson E. Whitney II got a signed confession from the fiancé.

Even though Richardson was viewed as a victim of injustice, Depue disagreed and made a compelling argument as to why he was guilty of killing his seven children.