After improving his record to 14–0, Mayweather earned a title shot on January 19, 1983, against lineal and WBA super featherweight champion, Samuel Serrano.

[3] Mayweather made two successful title defenses against Jorge Alvarado and Benedicto Villablanca before suffering his first loss via first-round knockout against Rocky Lockridge on February 22, 1984.

Mayweather won the IBF-USBA super featherweight title when he gave Kenny Baysmore his first loss, by TKO in round three.

Thus, Mayweather earned the opportunity to fight against WBC super featherweight champion, Julio César Chávez, on July 7, 1985.

Mayweather made four successful title defenses before he encountered Mexican champion Julio César Chávez again on May 13, 1989.

He fought Rafael Pineda for the vacant IBF light welterweight title on December 7, 1991, but he lost by KO in round nine.

On March 14, 1993, Mayweather beat former WBA lightweight champion, Livingstone Bramble by corner stoppage in round five.

In his next fight, against Johnny Bizzarro on August 4, 1994, Mayweather won the IBO welterweight title by unanimous decision.

Near the conclusion of the tenth round, Judah hit Mayweather with a left hand that was clearly below the belt and followed up with a right-handed rabbit punch.

Five days after the fight, the Nevada State Athletic Commission decided not to overturn the result of the bout, but Roger Mayweather was fined US $200,000 and suspended for one year.

Mayweather allegedly hit her several times in the ribs, then tried to choke her, causing her to spit up blood when police arrived.

Appearing on the HBO series 24/7, Mayweather admitted to choking St. Vil in an effort to restrain her, but denied that he physically struck her.