He began piano studies at the Conservatoire régional du Grand Nancy, where he won, at age 14, a gold medal in the Hugues Leclère's class.
Later, he continued his studies first with Jacques Rouvier and then Bruno Rigutto, during which time he was awarded a scholarship by the Meyer Foundation for cultural and artistic development, and made a recording of works by early twentieth-century composers.
He has been also awarded prizes at other international competitions (Vlado Perlemuter, Shanghai, Hamamatsu, Alessandro Casagrande), and has received the support of the Yamaha and Natexis Banques Populaires foundations.
Romain Descharmes has also participated in numerous broadcasts for television and radio (France Musique, Mezzo TV, NHK Japan).
He has collaborated with such artists as Roland Daugareil, Henri Demarquette, Laurent Korcia, Sarah Nemtanu, the Court-Circuit Ensemble, the Ebène Philarmoniker Quintette.