The Roman Catholic Archdiocese of Blantyre (Latin: Archidioecesis Blantyren(sis)) is the Roman Catholic archdiocese for Blantyre in Malawi.

The cathedral church of the archdiocese is the Our Lady of Wisdom Cathedral, Blantyre.

The Archdiocese of Blantyre is 9,166 square miles (23,740 km2).

Out of a total population of 4,600,000, there are 1,133,850 Catholics.

Currently, Thomas Luke Msusa SMM is the bishop of the diocese.