The Roman Catholic Archdiocese of Santa Cruz de la Sierra (Latin: Archidioecesis Sanctae Crucis de Sierra) is an ecclesiastical territory or diocese of the Roman Catholic Church in Bolivia.

It was erected as the Diocese of Santa Cruz de la Sierra by Pope Paul V on July 5, 1605, and was elevated to the rank of a metropolitan archdiocese by Pope Paul VI on July 30, 1975, with the suffragan see of San Ignacio de Velasco.

The seat of its archbishop is Cathedral-Basilica of San Lorenzo.

The current archbishop of Santa Cruz de la Sierra is René Leigue Cesari.

founded July 5, 1605 elevated July 30, 1975