The Diocese of Hoima, whose evangelization was spearheaded by the Missionaries of Africa (White Fathers), was erected on 9 August 1965, being made up of areas cut from the then Fort Portal Diocese and Lubaga Archdiocese.

Deogratias Muganwa Byabazaire succeeded Baharagate on 9 Mar 1991, serving as bishop until his death on 8 February 2014.

On 30 November 2015, Vincent Kirabo was appointed Bishop of Hoima, to succeed the late Byabazaire.

About 25% of the entire population are settlers and refugees from the Democratic Republic of Congo, Rwanda, the Sudan, and other national ethnic groups.

Ordained Priest at Bujumbura, Hoima, on 9 August 1969, Deogratias Byabazaire died 8 February 2014 morning at Entebbe Airport on his way back to Uganda.

On 13 November 2009 Pope Benedict XVI appointed him apostolic administrator "sede plena et ad nutum Sanctae Sedis" of Hoima Diocese.

At the time of his appointment, he was Professor of Theology at Ggaba National Seminary in Kampala, Uganda.