The Diocese of Uyo (Latin: Uyoën(sis)) is a Latin Church ecclesiastical territory or diocese of the Catholic Church in Nigeria.

Its episcopal see is Uyo.

The Diocese of Uyo is suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of Calabar.

The diocesan cathedral is Christ the King Cathedral in Uyo.

This article about a Roman Catholic diocese in Nigeria is a stub.