Following the Arauco War Bishop Don Reginaldo de Lizárraga went to the King Felipe III to obtain from the Pope the annexation of his Bishopric to the one of Santiago, to which the Supreme Pontiff acceded provisionally.

On February 18, 1585, the third Bishop of Santiago in his detailed report to King Felipe II mentions the missions of "Longomilla and Purapel", "Chanco and Loanco" taken care of by the presbítero Francisco de Maestanza, with a salary of three hundred and eighty pesos in gold and food.

The Cathedral Church of San Ambrosio, of Linares Diocese, is considered to be one of the most important and finest religious buildings erected in Chile in the twentieth century.

The new cathedral was conceived by bishop Juan Subercaseaux Errázuriz and its works were conducted by the renowned Chilean architects Carlos Bresciani and Jorge del Campo, the same duo that would be responsible, several years later, for the construction of another remarkable religious building, that of the parish church of Sagrado Corazón (Sacred Heart) in Providencia, Santiago de Chile.

Subercaseaux gave a great initial impulse to the construction of the Linares Cathedral, which has been characterized as "the plastic expression of his refined artistic culture".

In his travels abroad, he was untiring to ask for greater resources for his diocese, which badly required some material aid that would help to finance the cathedral works and additional priests.

The cathedral apse is remarkable for the outstanding mosaic work made by the Italian-born artist Giulio Di Girolamo.

Francisco Lavín, Juvenal Pereira, René González, Erasmo Salazar, Plácido Grove, Hernán González, Rolf Schnitzler, Gabriel Lacaux, Jaime Vallet, Ramón Iturra, Luis Alarcón, Germán Cáceres, Silvio Jara, Lorenzo Solari, José Ulloa, Luis Retamal, Benjamín Retamales, Francisco Hormazábal, José Prado, Gonzálo Aravena, Luis Fuentealba, Raúl Moris, Alejandro Quiroz, Waldo Alfaro, Mario Agurto.