The Diocese of San Carlos (Latin: Dioecesis Sancti Caroli Borromeo) is a Latin Church ecclesiastical jurisdiction or diocese of the Catholic Church in the Philippines.

The diocese was split off from the Diocese of Bacolod together with the Diocese of Kabankalan in 1987 and is a suffragan in the ecclesiastical province of the metropolitan Archdiocese of Jaro in Iloilo City.

The seat of the cathedral is the San Carlos Borromeo Cathedral in San Carlos City, Negros Occidental.

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