The Diocese of San Jose de Antique (Lat: Dioecesis Sancti Iosephi de Antiquonia) is a diocese of the Roman Rite of the Latin Church of the Catholic Church whose cathedral is in the municipality of San Jose de Buenavista, Antique in the Philippines.

On June 18, 1962, Pope John XXIII erected the Territorial Prelature of San Jose de Antique with the Apostolic Constitution "Novae cuiusque Ecclesiae constitutio".

On November 15, 1982, Pope John Paul II elevated San Jose de Antique and other territorial prelatures to the rank of diocese while remaining a suffragan to Jaro.

On January 7, 2019, after a year Pope Francis appointed Msgr.

Marvyn Maceda, Vicar General of the Roman Catholic Diocese of Naval in Biliran, as the 5th Bishop of San Jose de Antique.