The Roman Catholic Diocese of Tacna and Moquegua (Latin: Dioecesis Tacnensis et Moqueguensis) is a suffragan diocese of the Metropolitan Archdiocese of Arequipa in southern Peru, comprising the lay administrative regions Tacna Region and Moquegua region.

On 18 December 1944 Pope Pius XII established the Diocese of Tacna from the territory of the Archdiocese of Arequipa.

John Paul II renamed it the Diocese of Tacna and Moquegua on 11 July 1992.

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