[2] Chambers gained recognition for his skills on the Weaverville College baseball team in the late 1890s.

Following his collegiate season in 1899, Chambers attended spring training with the Boston Beaneaters in 1900 but did not secure a spot in the starting rotation.

[1] He relieved pitcher Bill Dinneen during the sixth inning of a game against the New York Gothams, but faced control issues, as indicated by a summary from the National Baseball Hall of Fame and Museum.

[3] Following his brief stint in the majors, Chambers played with minor league teams in Toronto and Indianapolis before fading from the baseball scene.

[3] He has been described as being Western North Carolina's first homegrown athlete to play Major League Baseball.