Kramer attended the University of Michigan from 1953 to 1957, winning a total of nine varsity letters in football, basketball, and track.

Kramer was selected by Green Bay with the fourth pick in the 1957 NFL draft and played for the Packers for seven seasons (1957, 1959–1964).

Altogether, Kramer won a total of nine varsity letters in his three sports — the maximum number possible, as freshmen did not have athletic eligibility at the time.

[5] As a 19-year-old sophomore, Kramer started all nine games at left end for the 1954 team that finished the season ranked #15 in the final AP Poll.

[6] As a junior in 1955, Kramer started six games at left end and Michigan finished 12th in the final AP Poll.

[9] For the season as a whole, he caught 12 passes for 224 yards and four touchdowns,[7] and he was selected as a consensus first-team end on the 1955 College Football All-America Team.

[10] Kramer had his best collegiate season as a senior, starting all nine games in 1956 and the Wolverines ended at seventh in the final AP Poll.

Bennie Oosterbaan, Kramer's football coach at Michigan, described his blocking and tackling ability as his most valuable asset.

Oosterbaan said this of his star player:"To top off his marvelous physical gifts of size and speed and strength, plus an uncanny coordination, Kramer was one of the fiercest competitors I've ever seen.

He handled 31 punts for a 40.6 yard average, kicked two field goals, and successfully converted 43 of 51 extra point attempts.

[1] He missed the entire 1958 season due to service in the U.S. Air Force,[3][18] and the Packers had the worst record in the league at 1–10–1.

[1] In 1962, Kramer caught 37 passes for 555 yards and seven touchdowns and was selected to play in the Pro Bowl and as a first-team All-Pro player.

In the 1961 NFL Championship Game, a 37–0 win for the Packer over the New York Giants, Kramer was the leading receiver, catching four passes for 80 yards and two touchdowns.

[23] Three weeks later, Kramer announced that, despite receiving offers to play for several other teams, he was resigning from football to assume a position as vice president of Paragon Steel Corp. in Detroit.

[24] Kramer later described his years with the Lions as "awful" and called head coach Harry Gilmer "the dumbest guy I ever met.

[26] He spent 22 years at Paragon before establishing Ron Kramer Industries in 1981, a company which is still in business today.

87 jersey will wear a patch over the left upper chest honoring Kramer, and dress at a locker labeled with a plaque bearing his name and time of tenure at Michigan.