[11] Woodroof's final years became the basis of the 2013 film Dallas Buyers Club, in which he was portrayed by Matthew McConaughey.

The movie Dallas Buyers Club depicts Woodroof as holding homophobic views prior to contracting HIV.

He acquired nutritional supplements and drugs not approved by the FDA for use in the United States, which he found helpful in ameliorating his symptoms.

Woodroof established what he called the Dallas Buyers Club in 1988 as a front for distributing these drugs and other substances to AIDS patients.

[23] He was portrayed in the film by Matthew McConaughey, who won an Academy Award for Best Actor for his performance as Woodroof.