Previously, he held several faculty positions during 10 years at Albert Einstein College of Medicine in New York, where he was the Betty and Sheldon Feinberg Senior Scholar in Cancer Research.

[7] DePinho publicly announced his resignation as MD Anderson president on March 8, 2017, after scrutiny over the administration of the organization had put him in the spotlight.

"DePinho's five-and-a-half years at the helm of the world's largest cancer center were marked by unprecedented turbulence, questions of conflicts of interest, and unhappiness on the part of the faculty.

[9] This work led to a deeper understanding of telomerase and telomere dysfunction in cancer, aging and a range of degenerative diseases, including fibrosis.

DePinho's scientific program has made basic discoveries underlying cancer in the aged and factors governing acquired and inherited degenerative disorders.