Another notable difference is that, while US-2 exists in two segments with a gap between New York and Michigan, the Roosevelt Highway was contiguous by passing through Ontario.

The highway begins in Portland, Maine at Longfellow Square where it travels up State Street and out of town along what is now U.S. Route 302.

It continues through the Green Mountains to Grand Isle where it crosses Lake Champlain by ferry into New York.

At Moira, the trail headed north to follow along the Saint Lawrence River to Cape Vincent, then back to US 11 in Watertown, then along what was once US 104, now NY 104, into Rochester on Empire Boulevard.

A 1924 alignment bypassed Lewiston and instead continued along NY 104 into Niagara Falls where it crossed into Canada along the Honeymoon Bridge.

The route heads up Michigan's Upper Peninsula to Duluth, Minnesota and then through North Dakota and Montana following close to the path of the US-2 grade.

[3] The western terminus was at South Park Blocks in Portland, Oregon where a statue of the former president stood until 2020.