Throughout its run, main hosts included Rooster Teeth founders Gus Sorola, Burnie Burns, Geoff Ramsey and Joel Heyman as well as Gavin Free, Jack Pattillo and Barbara Dunkelman while Armando Torres, Griff Milton and Andrew Rosas acted as its final hosts.

In 2009 they began uploading podcast themed "let's play" style videos on Rooster Teeth's YouTube channel.

[14] A 2014 conversation on the podcast about a hypothetical scenario involving an immortal snail became the source of a recurring meme on social media.

Founder Burnie Burns was a regular host until September 2019, but briefly returned in 2020 before leaving the company that June.

[17] In May 2023, Sorola announced he would step down as the podcast's host in June, having worked on the show for 15 years since its inception.

[21] The podcast is largely a comedic commentary on the popular culture of the week, including video games, recent news, website features, sports, movies, and television shows.