She graduated from the Lomas de Zamora National University and began to work in 1983 on the popular Radio Belgrano, as an announcer and reporter.

In 1990, under a new management, the revamped channel 11 (Telefe) hired her to front the 7:00pm nightly news hour, alongside Franco Salomone, lasting until December 30, 1998, when she and hundreds of co-workers were sacked for a developing financial crisis in the company.

Lufrano appeared on the air again in 2000, providing commentaries and reading the news in a midday program that was broadcast on the América channel.

In 2003, she began a long-time career as a newscaster for the public network, and since 2006 shared the duties of manager of programming,[2] until 2008, when she resigned in the middle of a political crisis due to the agricultural strike.

After leaving the public eye, Rosario continued working as a manager of an online channel, focused on travelling across the globe, and since 2013, has a daily morning program on Radio Rivadavia.