The Rose Building is a historic high-rise office building in Downtown Cleveland's Historic Gateway District in the U.S. state of Ohio.

Built in 1902, the 10-story building stands 165 feet (50 m) tall, at the corner of Prospect Avenue and East 9th Street.

[2] The building was the home of the Cleveland-based health insurance group Medical Mutual of Ohio[3] from 1947 to 2023.

[5] In 1902, the building was considered too far out of the Cleveland central business district and was projected to fail to obtain any tenants.

[6] The building is a fine example of turn of the century architecture and continues to guard the much traversed street of Prospect Avenue.