It is managed by the Cambridge University Hospitals NHS Foundation Trust.

The facility originates from the Central Union Poor House Infirmary which was established on Mill Road in the 19th century.

[2] A new purpose-built facility, established with a significant donation from local philanthropist David Robinson and named after his mother, was opened on Addenbrooke's Hospital's Hills Road site in October 1983.

[2] A major expansion of the Rosie Hospital was opened by the Queen and the Duke of Edinburgh in May 2013 and 5,000 babies had been born there by November 2016.

[3] The facility is located adjacent to Addenbrooke's Hospital and contains 120 maternity and women's beds.