Beginning in December 2001, he covered movie premieres, the Academy Awards, two Winter Olympic Games, and other events.

[citation needed] Mathews appeared as a celebrity mob member on seven episodes of NBC's prime time game show 1 vs. 100 in early 2008.

Inside Dish became the official online web-shows for CBS's Big Brother and The Amazing Race.

[citation needed] Also in 2009, he co-hosted GSN's Big Saturday Night, a weekly game show.

Network's red carpet team, filling in for Ryan Seacrest as co-host with Giuliana Rancic for E!

In January 2011, Mathews starred in a pilot that he produced and co-wrote with fellow Chelsea Lately round table regular Heather McDonald.

[10] By September 2011, Mathews had left The Tonight Show returning for guest appearances including the "Woulda, Coulda, Shoulda" skit on December 14, 2011.

[14] At the end of 2015, Mathews began filling in as a guest host on Hollywood Today Live, which is syndicated on Fox.

[16] In 2018, Mathews was announced as one of the eleven houseguests competing on the first American edition of Celebrity Big Brother.

He finished in 2nd place, winning $50,000, and was voted as America's Favorite Houseguest earning an additional prize of $25,000.

[24] On February 23, 2021, Mathews announced his engagement to Wellinthon García, a Long Island educational administrator.